Integrated Drug Discovery
Offering End-to-End Solutions
Hit Identification / Characterization
Axcelead will design a robust HTS strategy, starting from assay development through hit characterization, based on 700+ HTS experiences. Using carefully curated library sets from 1.5 million compounds inherited from a pharmaceutical company, we have achieved a success hit identification rate of 90+%. We also focus on advancing hit compounds to development candidates efficiently. Annotation information from our database, medicinal chemist reviews, and high-throughput ADME tests can be utilized for hit prioritization. Through evaluating similar compounds from our compound library and utilizing high-throughput synthesis platform, we will prioritize the best hit chemotypes ensuring quality Lead Generation start.
- Compound Libraries
- Virtual Screening
- Target-Based High-Throughput Screening (HTS)
– Biochemical & Mass Spectrometry-Based Assay
– Cellular Assay
– Affinity Selection Mass Spectrometry (ASMS)
– Thermal Shift Assay (TSA)
– Fragment Based Drug Discovery (FBDD) - Phenotypic Screening
– Phenotypic Assay
– iPSC
– Target Deconvolution - New Modalities
– Targeted Protein Degradation
– RNA Targeting Drug - Hit Characterization
– Hit Expansion & High-Throughput Synthesis
– Structural Biology & Biophysics