Better Target

Axcelead offers fully integrated drug discovery services from target discovery to IND enabling translational research. To accelerate and increase success rate of your drug discovery, Axcelead’s experienced and collaborative team facilitates each stage of your drug discovery project with its professional expertise, state-of-the-art facilities, and pharma origin huge compounds library/database, delivering timely and cost-effective results.
Identify optimal targets in drug discovery from a multitude of perspectives and verify the validity of each
We could support the identification of novel "Drug Target" using both various biological platforms and our knowledges which we have validated more than 500 targets
Narrowing down promising compounds that act on identified drug discovery targets
9 months (from system construction with general target to hit identification); additional 3 months (profiling, initial synthetic development, and evaluation)
Axcelead enjoys a higher than 90% hit rate that ensures we are able to efficiently obtain high-quality hit compound information, backed by accumulated drug discovery data and more than 600 screenings
High-throughput screening — compound binding assay using affinity selection mass spectrometry (ASMS)
Generate a compound with an appropriate profile that qualifies as a lead compound
9 months
Axcelead offer integrated capabilities spanning the Lead Generation process. Our scientists, with their wealth of knowledge and experience, keep the project moving forward through high-level “design, synthesis, evaluation and analysis” cycle.
All-in-One Solutions for Candidates Generation
Optimize compounds and select the promising candidates with good efficacy, DMPK, and safety for clinical development
12 months
Cross-functionality supported by specialized teams, the primary one being our chemists who have considerable drug discovery experience, all who work in tandem to keep the project moving forward by rapidly putting the compounds through the “design, synthesis, evaluation and analysis” cycle
All-in-One Solutions for Candidates Generation
Based on the multiple compound evaluation results, coupled with the in-house development strategy, select candidate compounds suitable to move forward to the IND application stage
6 months
Given our experience in a pharmaceutical company, advancing many projects to the IND/NDA application stage, we are able to support the selection of candidate compounds for development using a multi-disciplinary approach to evaluation
Secure necessary data for the IND application, prepare and submit application documents, follow up as required with the regulatory agency, etc.
12 months
Drawing on our considerable experience in processing many IND applications in Japan, Europe, and the United States, not to mention our experience previously garnered while either working directly in a pharmaceutical company or as a consultant, we are confident in our ability to provide total support and smooth handling of your IND application and/or out-license
Axcelead efficiently discovers high quality hit compounds with integrated HTS platform and drives generation of Advanced hit compounds and prioritization of hit chemotypes with comprehensive activities by collaborating with highly experienced chemists and the ADME-Tox team
Axcelead provides comprehensive support for starting clinical trials and out-licensing by drawing upon our experience, which for many projects has led to a successful outcome for IND and NDA