Capabilities
Axcelead will offer a comprehensive set of best-in-class capabilities to meet a range of customer needs.
Research consulting
Over 200 highly qualified discovery scientists, headed by industry leaders with ~30 years’ experience:
- Chair of R&D Committee of JPMA1
- Board member of Kanagawa R&D Committee
- Board of Directors of Japan Bio-industry Association
- Board of Directors of The Research Foundation for Pharmaceutical Sciences
- Board of Directors of the Japanese Society of Toxicology
- Grand Review Committee of AMED
- Several ICH working team members
- Editorial board member of Medicinal Chemistry
Communications, Journal of Toxicologic Pathology - Foundation member of JBF2
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Biology
- In vitro/in vivo pharmacology for multiple TAs
- Molecular biology
- Multi-omics analysis using gene-edited cells/animals, patient samples and clinical information
- Bioinformatics
- Proprietary animal models, such as transgenic, knock out, humanized and immunodeficiency
Screening
- High-quality and diversified compound library of ~1.0 million compounds
- Compound library logistics (fully automated, state-of-the-art robotics)
- High throughput screening (~300,000 compounds/day) for multiple target classes with track record of more than 500 campaign
- In vitro assay (profiling) for Hit to Lead/Lead Generation/Lead Optimization
- Protein science and Bio-physical analysis
DMPK
- High throughput ADME screening
- In vitro/ in vivo DMPK studies for project start to IND (rodents and non-rodents)
- PK/PD analysis, modelling and simulations
- Human PK analysis and prediction
- Non-clinical / clinical bioanalysis and metabolite ID identification for multiple modalities
- Physical chemical profiling and solid form screening
- Pre-formulation studies
Chemistry
- Medicinal chemistry (Hit Identification, Lead Generation, Lead Optimization)
- Design and synthesis of novel compounds for multiple target classes (Kinase, Enzyme, GPCR, Ion Channel, PPI, etc. ) and multiple molecular classes (Small molecule, Macrocycle, Peptide, Nucleic acid)
- Peptide chemistry
- Computational chemistry (SBDD / LBDD / FBDD / Binding mode prediction / Dynamics simulation / Automated design / in silico screening / Library design)
- Cheminformatics
- High-throughput parallel synthesis
- Synthetic route design and Scale-up synthesis
- Labelled compound synthesis
- Analytical chemistry (X-ray, NMR, HPLC)
Toxicology
- Predictive toxicology
- GLP toxicology for IND
- Investigative toxicology
- Tumorgenic assessment of cell-therapy products
- Safety pharmacology
- Rodents and non-rodents studies available for both toxicology and safety pharmacology

Animal care (collaboration with Takeda Rabbics)
- AAALAC and GLP Accredited Animal Care & Use program
- Veterinary service
- (Animal breeding)