Axcelead strongly supports research in drug discovery for cancer immunotherapy, focusing on immune profiling within a tumor.
Optimal solutions in drug discovery for cancer immunotherapy are proposed and implemented, accelerating advancement in this field.
A multi-faceted approach to immune profiling within a tumor
In addition, please consult Axcelead regarding an effective test design using the latest analytical techniques!
- Single-nucleus RNA-seq： Comprehensive population analysis using a frozen sample
- Omics analysis： Biomarker exploration and MoA analysis using proteomics and metabolomics.
- Multiplex immunostaining： Spatial assessment of immune cell localization
- Spatial transcriptomics： Assessment of local pathological changes linked to genetic information
As experts in drug discovery and as a partner to our customers,
we provide total support in drug discovery research in the field of cancer immunity
Ex.1 : in vitro assessment of immune cells
In drug discovery research in the field of cancer immunotherapy, assessment of complex biology is required and usually requires in vivo tumor models. However, differences between animal species and low throughput are issues in an in vivo model. Although reproducing the tumor environment in vitro is not simple. Axcelead can successfully design and construct an appropriate in vitro testing system that can meet your objective, and perform PoC confirmation and assessment of compounds.
Ex.2 : Assessment of drug efficacy using CAR-T cells
Therapeutic modalities, including cell therapy and gene therapy, are rapidly expanding within drug discovery research in the field of cancer. Axcelead has accumulated experience in small molecule drug discovery and has expanded the range of such modalities. An example of a test to assess anti-tumor efficacy using CAR-T is shown in the figure on the left. Axcelead can provide a test design which selects the most suitable model, considers the dosing regime, and includes a toxicity assessment.
Examples of how we can help
We provide flexible support according to your goals and conditions!
If you have any questions regarding drug discovery or pathological research related to cancer immunotherapy,
please contact Axcelead!