Drug Discovery for Heart Failure

Total support for the drug discovery in various modalities for heart failure, such as small molecule, regenerative medical products, nucleic acid drugs, etc.

Various modality approaches can be considered for the treatment of heart failure, for which the only complete cure is still heart transplantation using organs donated from brain-dead patients.
Axcelead conducts pharmacological studies using various pathophysiological animal models such as mice and rats. In addition, we can support development of human-derived regenerative medical products through large animal heart failure models like cynomolgus monkeys and minipigs.

Step 1. Target identification/validation (KO/Tg mice, etc.)

Step 2. High-Throughput Screening

Step 3. Cell assay

Step 4. Animal disease model assessment

Pharmacological study using immunosuppressed pigs