Total support for the drug discovery in various modalities for heart failure, such as small molecule, regenerative medical products, nucleic acid drugs, etc.
Various modality approaches can be considered for the treatment of heart failure, for which the only complete cure is still heart transplantation using organs donated from brain-dead patients.
Axcelead conducts pharmacological studies using various pathophysiological animal models such as mice and rats. In addition, we can support development of human-derived regenerative medical products through large animal heart failure models like cynomolgus monkeys and minipigs.
Step 1. Target identification/validation (KO/Tg mice, etc.)
- Identification of target candidates by comprehensive gene expression analysis using patient samples and/or disease model samples
- Verification of drug efficacy in animal disease models using commercial compounds, antibodies, etc. of target candidates
- Cardiac hypertrophy and heart failure are induced by creating KO mice of target candidate molecules, and the improvement/exacerbation results are verified.
Step 2. High-Throughput Screening
- Using the full range of the industry’s largest and high level high quality compound library and various high-throughput screening technologies, high quality hit compounds for a wide range of targets can be provided.
- HTS（High-Throughput Screening）
Step 3. Cell assay
- Compound candidates for in vivo evaluation are selected according to various assays, such as the assessment of cardiac hypertrophy using human iPS-derived myocardial cells.
Step 4. Animal disease model assessment
- We have a variety of heart failure models and can propose the most suitable animal disease model and assessment system to meet your needs.
- We can also evaluate regenerative medical products such as iPC cells using immunosuppressed large animal heart failure models.
- We conduct PK/PD analysis of compounds including nucleic acid, and select appropriate compounds for examination by animal disease models for our clients.
Pharmacological study using immunosuppressed pigs