HTS (High-throughput screening) is a service to identify hit compounds with high probability in a short period of time.
Related Solution
High-throughput screening for ion channel drug discovery
Our HTS platforms and services for your drug discovery
- Seamless services from assay development through hit/lead finding with well-experienced and high expertise
- HTS platform covering a wide range of target classes and phenotypes
- Pharma-origin vast library with high quality and diverse structure
- One-stop Hit follow-up service
Seamless screening platform from assay development
through HTS with well-experienced and high expertise professionals
- Axcelead offers an integrated screening platform including material preparation, assay development, and HTS.
- Axcelead proposes promising flexible screening plans and strategies based on customer needs.
Axcelead provides hit compounds including high-value information.
■ Compound profiles based on Axcelead original data.
- Cytotoxicity data (only for compounds tested in-house so far)
- Biological annotations of hit compounds
■ Review of hit compounds by medicinal chemists in Axcelead
- Clustering of hit compounds by Axcelead original algorithm
- Comments on structural characteristics of each cluster
■ Drug-like properties (QED, HBA/HBD, AlogP, tPSA, number of aromatic ring, Fsp3 etc.)
Assay development and high-throughput screening platforms
covering a wide range of target classes
- Platforms are available for all major target classes and phenotypes.
Axcelead proposes and conducts suitable material preparation (recombinant proteins and stable cell lines) for your HTS.
Major Axcelead assay platforms
- GPCRs
- Enzymes
- Ion channels/Transporters
- Nuclear receptors
- PPI (protein-protein interaction)
- Nucleic acids (RNA targeted drugs etc.)
- High-throughput Affinity Selection Mass Spectrometry (ASMS) for screening
- Phenotypic screening
e.g.) High content screening, Reporter gene assayGene expression analysis
Vast compound libraries with high quality and diverse structure
Axcelead proposes the optimal compound libraries for your HTS.
■Diversity libraries
Single library 129,000 compounds
Pooled library 500,000 compounds
(Standard 320,000 cpds)
You can choose either or both of pooled and single libraries that pursue lead-likeness and diversity. CNS focused, Fragment, and low cytotoxic compounds for cell-based screening libraries are available
■Focused libraries 41,000 compounds
- Libraries for target classes (Kinase, GPCR, Protease, PPI, etc.)
- Macrocyclic
- RNA
- Covalent
- Extended rule of 5
- Natural product
- Annotation
Biologically annotated library for phenotypic screening is available
High quality compound library
< For customers who have received our HTS service >
One-stop Hit follow-up service after HTS
Axcelead supports to generate Advanced Hit compounds with several approaches to prioritize your hit chemotypes.
Axcelead biophysical analysis
- Affinity selection-mass spectrometry (AS-MS)
- Thermal shift assay (TSA)
- Nuclear Magnetic Resonance (NMR)
- Isothermal titration calorimetry (ITC)
- Surface plasmon resonance (SPR)
- X-ray crystallography
We can also support Target Validation. Please feel free to contact us.
Service Material
Integrated HTS platform for innovative drug discovery
- Screening