Our support doesn’t just stop at clearn staining

Axcelead’s integrated services provide
maximum assessment of in vivo reactions

With a Biology Team and Pathology Team working together under one roof,
we’ll design tests to assess your drugs waste-free.

Our one-stop assessment service
will give you accurate results, fast.

Pharmacological assessment and image analysis of inflammatory cells, using model mice with colitis:

Image analysis:

1. Original2. MarkupBrown: MPO signalMeasure immunoreactive cells (3+=Red, 2+=Orange, 1+=Yellow, 0=Blue)

1. Immunohistochemistry using anti-MPO antibodies* was performed on intestinal tissue samples taken from the mice.
*: Neutrophil markers
2. The Intensity of the immunopositive signals (brown) was quantified using image analysis software.

IHC of Neutrophil Marker(myeloperoxidase, MPO) 3. Vehicle Treat

3. The results clearly showed that administering the drug significantly reduced neutrophilic infiltration in model mice with colitis.
→→Separate quantitative analysis for each cell species can also be performed by changing the antibodies used.


Experimental Colitis(naïve T cell-transferred colitis model)

Pharmacological studies in our Biology TeamDepartment

■Oncology, immunology, metabolism, central nervous system, and more…Axcelead’s Biology TeamDepartment can cover a vast range of disease areas.
■ We also have a wealth of experience with pharmacological study using pigs and monkeys.
■ We can rapidly create KO/KI genetically modified rodents
(Using CRISPR/Cas9* technology, we can create KO rodents within three months)
*: Axcelead has a commercial license agreement from ERS genomics.

Quantifying image data in the Pathology Team

■ We can assess all organs. With technology and quality backed up by safety research, we can prepare samples of all organs and tissues and assess their pathology.
■ Being involved right from the test design stage means we can prepare the most suitablebest possible samples for assessment.
■ We can also conduct the condition settings of support IHC and ISH conditions for target markers.
■ Please ask consult us about acquiring and analyzing whole slide images, too.

Axcelead has everything you need for drug discovery, all under one roof.

Other Integrated Solution

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