Axcelead Drug Discovery Partners (ADDP) fully contributes to your pipeline generation through Axcelead Hit-identified Target(A-HiT) which is a target collection of potential drug candidates. A-HiT project, originated from A-HiT, includes Hit/Lead compounds and assay systems, and enables generation of a high-quality and promising candidate compound in the shortest approach. ADDP scientists not only possess deep knowledge and extensive experience of drug discovery research but also can access various data, which obtained in the pharmaceutical company, such as target proteins, assay/evaluation systems, solutions for ADMET issues, SAR information, X-ray co-crystal structures. We work together with you to promote the drug discovery project and contribute to your pipeline generation efficiently and effectively.
1．What is A-Hit project?
2．An Example of Research Flow
3．Track Record
What is A-Hit project?
✓Start your research from lead generation or optimization stages
- The A-HiT project aims to generate candidate compounds by utilizing existing data/information including Hit/Lead compounds and assay systems that have already obtained in the pharmaceutical company.
- Those data and information can significantly shorten the early drug discovery process.
- The intellectual property rights of the compounds designed and synthesized in the A-HiT project generally belong to the customer.
✓Offer high-potential targets for successful drug discovery
- Around 50% of targets in A-HiT cover “First-in-Class”.
- Targets from A-HiT also have the potential for drug repositioning. ADDP can offer target validation study in your focused disease areas and/or address unmet medical needs.
- Co-crystal structures of the target protein and its ligand have already been available in 30% of targets in A-HiT.
- In vitro/in vivo POC in original indication has been already confirmed in many A-HiT projects.
✓Lead you to the goal with the optimal research plan and the best team
- ADDP develops an efficient research plan based on our knowledge, success and failure experience and data of the target and its related compounds.
- Our research plan enhances the probability of research success.
- Most of the project leaders and members of the A-HiT project are quite familiar with the project due to their past participation.
- ADDP covers full functions for lead generation and optimization stages of the drug discovery research, enabling us to implement a speedy and high-quality “design-synthesis-evaluation-analysis” cycle.
An Example of Research Flow
- Based on the customer’s research structure and needs, the project leader and members will be assigned from each research function of ADDP to work together with the customer to advance the project as one team.
- We are sure that a candidate compound can be identified within two years after lead optimization(LO) entry.
Track Record
We have already collaborated with a number of global customers, such as Otsuka Pharmaceuticals in CNS area and Evommune in inflammation area.
・Otsuka Pharmaceutical and Axcelead Drug Discovery Partners announce joint research in CNS indications
・Evommune and Axcelead Drug Discovery Partners Launch A Collaboration On A PKCtheta Program To Kick-off Evommune’s Inflammation Pipeline
Please feel free to contact us if you
want to increase the efficiency and speed of your drug discovery research
want to expand your pipeline with new projects that your company does not currently have
want to reduce initial investment in a project
If your target of interest is in A-HiT, you can obtain a Powerful Jump Start toward Candidate Selection!